Weight Loss Injections Ozempic and Wegovy: Revolution or Overhyped Miracle Cure?

Weight loss injections such as Ozempic, Mounjaro, and Wegovy are currently making headlines. Originally developed to treat type 2 diabetes, they are now experiencing a surge in popularity as so-called miracle drugs for weight reduction.

Social media, fueled by influencers and celebrities, has accelerated the spread of information about these medications. But how do weight loss injections actually work? Who are they suitable for, and what risks do they pose? A closer look at the facts reveals that these injections can be effective—but only in the right context and under medical supervision.

To shed light on the topic, we spoke with Dr. Katharina Sandtner, the medical director of the health department at Lanserhof Lans, about these so-called miracle injections.

Weight loss injections contain active ingredients that mimic so-called incretins. Incretins are naturally occurring gut hormones that play a crucial role in regulating blood sugar metabolism.

“These gut hormones are also called incretins. They have a significant impact on blood sugar metabolism. The special feature of these medications is that they occupy the body’s own receptors and thus have a long-lasting effect—up to a week.” (Dr. Katharina Sandtner / Lanserhof Lans)

The Key Effects of Weight Loss Injections:

• Slowed Gastric Emptying: Food remains in the stomach longer, leading to a prolonged feeling of fullness.
• Reduced Appetite: The active ingredients influence the brain’s satiety center, resulting in less hunger.
• Optimization of Blood Sugar Metabolism: The medications promote insulin secretion, helping transfer sugar from the bloodstream into the cells.

The reason these medications are so effective lies in their long-lasting effects. While naturally occurring gut hormones are active for only a few minutes, the active ingredients in weight loss injections last up to a week. As a result, it is sufficient to inject the medication only once a week.

Originally, weight loss injections were approved for the treatment of type 2 diabetes. The effect of weight reduction was initially observed as a side effect. Meanwhile, they have also been approved for patients with obesity (BMI ≥ 30) or overweight in combination with comorbidities (e.g., high blood pressure or insulin resistance).

A problematic aspect is the so-called off-label use: In this case, the medications are used without a medical indication—often for purely aesthetic reasons.

“This is almost creating a black market. As a result, type 2 diabetics or severely obese individuals are missing out on an important medication.” (Dr. Katharina Sandtner / Lanserhof Lans)

Since these medications require a prescription and are not yet covered by health insurance, gray areas emerge, posing challenges for both doctors and patients.

Weight loss injections are considered revolutionary because they offer a new approach to weight reduction that directly influences biochemical processes in the body. Diets and lifestyle interventions often require long-term commitment, whereas the injections deliver results relatively quickly.

“The mechanism of action of these injections is unique because the body’s own incretins are only active for a few minutes. The medications extend this effect to a full week.” (Dr. Katharina Sandtner / Lanserhof Lans)

However, the expert urges caution:

“As in all areas of medicine, the dose makes the poison. Anything that is done too quickly and without control increases the risk of side effects.”

No medication is free from side effects—and weight loss injections are no exception. The most common issues affect the gastrointestinal tract:

• Nausea
• Feeling of fullness
• Constipation

These symptoms result from delayed gastric emptying, which affects the digestive process.

“The most common side effects are a feeling of fullness, nausea, and constipation. It’s easy to imagine that this is dose-dependent and can strain the gastrointestinal tract.” (Dr. Katharina Sandtner / Lanserhof Lans)

Another phenomenon is the so-called “Ozempic Face”: Due to rapid fat loss, aesthetic changes in the face may occur. This primarily affects connective tissue and collagen breakdown.

Long-term effects are still unclear, as these medications have only been on the market for a few years.

“There is a lack of long-term studies. We do not yet know what the consequences could be in 20 years.” (Dr. Katharina Sandtner / Lanserhof Lans)

Weight loss injections are not a home remedy. They require medical supervision and monitoring. Before starting therapy, laboratory tests must be conducted to detect potential risks early:

• Blood lipid levels
• Liver values
• Pancreatic enzymes

“It’s not just about losing weight but also about managing obesity-related comorbidities.” (Dr. Katharina Sandtner / Lanserhof Lans)

At the same time, therapy should not be viewed in isolation. A comprehensive program including nutritional counseling, exercise therapy, and lifestyle changes is crucial for long-term success.

Weight Loss Injections Can Be Helpful, but They Are Not a Substitute for a Healthy Lifestyle

“The original idea of a treatment is not to lose weight, but to relearn how to eat.” (Dr. Katharina Sandtner / Lanserhof Lans)

Mindful eating, chewing slowly, and timing meals correctly help promote the natural feeling of fullness—without the need for medication.

The medications can be prescribed by general practitioners and specialists such as endocrinologists. Since they are prescription-only, medical supervision is essential.

“It is particularly important to inform patients about the effects and side effects.” (Dr. Katharina Sandtner / Lanserhof Lans)

Weight loss injections offer a promising option for weight reduction—especially for people with obesity or accompanying metabolic disorders. However, they are not a miracle cure and only work effectively as part of a holistic treatment plan.

“The quickest way is often not the right way.” (Dr. Katharina Sandtner / Lanserhof Lans)

Those interested in treatment should consult experienced doctors to make an informed decision. Dietary changes, exercise, and long-term lifestyle changes remain the key components for sustainable success.

At Lanserhof, we take a holistic, medically supervised approach to weight management, ensuring that the benefits of medications such as Weight Loss drugs (ie Ozempic, Mounjaro, Wegovy amongst others) are maximized while potential side effects are carefully managed.

Unlike conventional weight-loss treatments, our comprehensive programme integrates cutting-edge diagnostics, tailored lifestyle interventions, and targeted therapies to support long-term health.

More Than Just Medication

While GLP-1 receptor agonists (such as weight loss drugs) have transformed weight management, they can also lead to muscle and bone density loss, metabolic changes, and structural alterations in key organs, including the thyroid and abdominal organs.

At Lanserhof, we take a proactive, personalized approach, using advanced diagnostics including device-based assessments and laboratory analyses to detect and mitigate these risks at an early stage.

A Personalised, Multi-Faceted Approach

Rather than relying on high medication doses, we prioritize precision medicine, combining:

– Expert-led medical, nutritional, and sports guidance to optimise results

– Lanserhof Therapy, addressing gastrointestinal and musculoskeletal concerns

– Supplementation and tailored interventions to counteract potential deficiencies

Enhancing Metabolism and Recovery

To further support the body’s adaptation, we integrate if appropriate in the specific case:

– Cold Chamber Therapy, which stimulates metabolism and alleviates joint discomfort

– Healing Mud Baths, used to support musculoskeletal health and overall recovery

– IHHT techniques (Intermittent Hypoxia-Hyperoxia Training (IHHT) such as Cellgym to stimulate cellular and metabolic adaptation leading to improved function and resilience

– Plasma stream therapy

– Hypnosis

– Psychotherapy and Energy medicine

This programme is designed not only to enhance the efficacy of treatment but also to ensure it remains safe, sustainable, and fully tailored to each individual alongside our Lanserhof principles.

We look forward to welcoming you to Lanserhof and introducing you to this pioneering approach to weight management.

At Lanserhof, you will receive tailored support on your journey to your desired figure and greater well-being. With professional medical supervision, individual dietary programs, and exercise therapies, you will be guided step by step towards a healthy lifestyle.

Contact us now and start your personal health journey with the experts at Lanserhof – for sustainable success and a new sense of life!

The most commonly used weight loss injections are based on active ingredients that mimic the body’s natural gut hormone GLP-1 (Glucagon-like Peptide-1). This hormone regulates blood sugar levels, promotes insulin secretion, and influences the feeling of satiety. Currently, two main active ingredients are in use:

1. Semaglutide (Ozempic® and Wegovy®)

• Applications:
  Semaglutide was originally developed for the treatment of type 2 diabetes and approved under the name Ozempic®. Since January 2022, it has also been available under the name Wegovy® specifically for weight reduction in obesity.
• Effects:
  Semaglutide enhances and prolongs the feeling of fullness by slowing gastric emptying and promoting insulin secretion. This leads to a reduction in calorie intake and supports weight loss. Studies show that patients using Semaglutide in combination with lifestyle changes can lose up to 20% of their body weight.
• Availability and Restrictions:
  In Germany, Wegovy® has been available since July 2023. However, it is not covered by statutory health insurance as it is classified as a lifestyle drug. A prescription is only available for patients with a BMI ≥ 30 or a BMI ≥ 27 in combination with weight-related conditions.

2. Mounjaro® (Tirzepatide)

• Indications: Mounjaro® is a relatively new medication for the treatment of obesity and type 2 diabetes. It contains the active ingredient Tirzepatide and was approved by the FDA in 2022 for the treatment of obesity. Mounjaro® is also prescribed for weight loss in adults with a BMI ≥ 30 or ≥ 27 with comorbidities such as high blood pressure or elevated blood lipid levels.

• Mechanism of Action: Tirzepatide is a dual GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Peptide) receptor agonist, meaning it targets two different receptors in the body. This dual effect leads to a stronger suppression of food intake, improved blood sugar control, and enhanced satiety. Mounjaro® promotes delayed gastric emptying and increases insulin secretion, thus reducing appetite while lowering blood sugar. Studies show that patients on Mounjaro® can achieve an average weight loss of 15-20% of their body weight.

• Administration and Limitations: Mounjaro® is administered as a weekly injection, which makes it more convenient compared to daily injections like Liraglutide. It is injected subcutaneously, typically in the abdomen or thigh, and the once-weekly dose offers greater convenience for users.

Conditions for Prescription: Like Liraglutide, Mounjaro® is a prescription medication and is only prescribed under specific conditions: • BMI ≥ 30 or • BMI ≥ 27 with comorbidities such as high blood pressure, elevated blood lipids, or type 2 diabetes.

It is not suitable for: • Pregnant or breastfeeding women, • Children under 18 years, • People with severe kidney insufficiency or other serious health issues that may contraindicate the use of Mounjaro®.

A Look Into the Future: Weight Loss Injection 2.0

New medications such as Tirzepatide represent another advancement. They combine the effects of GLP-1 with a second hormone, GIP (Glucose-Dependent Insulinotropic Polypeptide). Early studies show even greater weight reduction—comparable to the results of bariatric surgery. Tirzepatide is currently only approved in Europe for the treatment of type 2 diabetes, but its suitability for weight loss is being evaluated.

Important: No matter how promising these medications sound, long-term success requires lifestyle changes. Without dietary adjustments and exercise, weight regain often occurs after stopping the injections.

Recommendations from the German Obesity Society (DAG)

1. What is the basic therapy for obesity, and what role do medications play?
The foundation of any obesity treatment is the so-called basic therapy, which includes nutritional, exercise, and behavioral interventions. Medications such as semaglutide or liraglutide are only used when these measures alone are insufficient to achieve adequate weight loss. Medications should complement, not replace, basic therapy.

2. Which weight-loss medications are approved in Germany?
Currently, the following medications are approved for weight reduction:
• Orlistat: Inhibits fat digestion and reduces calorie absorption, but has limited effectiveness (an average weight loss of 4 kg per year) and frequent side effects such as fatty stools.
• Liraglutide (3 mg): A GLP-1 receptor agonist that must be injected daily, leading to an average weight loss of 8% after one year.
• Semaglutide (2.4 mg): A GLP-1 receptor agonist that is injected weekly, resulting in an average weight loss of up to 15% after one year.

3. Is long-term use of these medications necessary?
Yes, most patients need to take these medications long-term to maintain weight loss. Discontinuation often leads to weight regain. Research on potential interval therapies is still insufficient.

4. What is the cost of weight-loss injections, and are they covered by insurance?
The costs for semaglutide or liraglutide range from several hundred euros per month, depending on the dosage and brand. In Germany, patients generally have to cover these costs themselves, as medications for weight regulation are not reimbursed by statutory health insurance (§ 34 SGB V). No changes to reimbursement policies are currently planned.

5. What are the risks associated with GLP-1 receptor agonists?
Side effects primarily affect the gastrointestinal tract, including nausea, vomiting, or constipation. In rare cases, more severe side effects such as acute pancreatitis or a potential risk of thyroid cancer may occur. Therapy should always be conducted under medical supervision.

6. Are weight-loss injections suitable for everyone?
No. Weight-loss injections are approved for individuals with:
• A BMI ≥ 30 or
• A BMI ≥ 27 with comorbidities (e.g., high blood pressure, type 2 diabetes).

They are not suitable for:
• Pregnant or breastfeeding women,
• Individuals with type 1 diabetes,
• People with severe liver or kidney diseases.

7. Why is medical supervision essential?
Using weight-loss injections requires close medical supervision to detect side effects early and tailor therapy to individual needs. Additionally, basic therapy (nutritional counseling, exercise therapy) must be implemented alongside medication to achieve long-term success.

8. Are there alternatives to medications for severe obesity?
Yes, alternative approaches may include:
• Bariatric surgery: Procedures such as gastric bypass or sleeve gastrectomy can lead to sustainable weight reduction and improvement of comorbidities.
• Intensive nutrition and exercise therapy: Especially in specialized obesity centers.
• Psychotherapeutic interventions: To address eating disorders or emotional eating behaviors.

9. How does media hype around weight-loss injections impact patients?
Media attention often creates unrealistic expectations and increases off-label use, particularly among individuals without a medical indication. This can contribute to the stigmatization of obesity patients and limit the availability of medications for those with a genuine medical need.

10. What is known about the long-term safety of these medications?
The long-term safety of semaglutide and liraglutide is still being researched. There are indications of potential risks, such as thyroid cancer, but conclusive data is currently lacking. Regular medical check-ups and reporting of side effects are therefore crucial.